| 发明名称 |
Method for making (-)-(2R,4S)-4-[(3,5-bis-trifluoromethyl-benzyl)-methoxycarbonylamino]-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester |
| 摘要 |
<p>A process for preparing (-)-(2R,4S)-4Ä(3,5-bis-trifluoromethyl-benzyl) -methoxycarbonyl-aminoÜ-2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quino line-1-carboxylic acid ethyl ester comprising combining (-)-(2R,4S)-4(3,5-bis-trifluoromethyl-benzylamino) -2-ethyl-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester, 4-toluene-sulfonate and sodium carbonate in tetrahydrofuran at a temperature of about 20 DEG C to about 25 DEG C in the presence of methyl chloroformate. <CHEM></p> |
| 申请公布号 |
EP1125929(A1) |
申请公布日期 |
2001.08.22 |
| 申请号 |
EP20000310064 |
申请日期 |
2000.11.13 |
| 申请人 |
PFIZER PRODUCTS INC. |
发明人 |
DAMON, DAVID BURNS;DUGGER, ROBERT WAYNE |
| 分类号 |
A61K31/445;A61K;A61K31/16;A61K31/435;A61K31/47;A61K31/4706;A61P3/06;A61P9/10;C07B61/00;C07C233/08;C07C235/66;C07D;C07D213/12;C07D215/00;C07D215/06;C07D215/20;C07D215/38;C07D215/42;C07D215/44;C07D215/48;C07D215/50;C07D217/00;C07D221/04;C07D311/58;C07D335/06;C07D401/04;C07J;(IPC1-7):C07D215/50 |
主分类号 |
A61K31/445 |
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