INTERMEDIATES USEFUL IN PRODUCING CARBAPENEM AND PROCESS FOR THE STEREOSELECTIVE PRODUCTION OF THE SAME

摘要

An efficient process for the stereoselective production of (2S,4S)-2-ÄÄ(R)-hydroxy-(3R)-cyclic amin-3-ylÜmethylÜpyrrolidine-4-thiol or its salts, which are intermediates useful in producing carbapenem, by reacting a compound represented by general formula (I) (wherein R<1> represents lower alkylsulfonyl, optionally substituted arylsulfonyl or alkylsilyl; and R<2> represents an amino-protective group) with a compound represented by general formula (II), wherein R<3> represents optionally substituted lower alkyl or aryl; X represents oxygen or sulfur; Y represents azido or nitro; and m is an integer of from 2 to 5.