| 摘要 |
The invention provides a method of treating any condition of elevated levels of unconjugated bilirubin in adults or children, such as Gilbert's syndrome or liver cirrhosis. The method calls for the administration of chrysin or chrysin analogs via dietary or other means. Also provided is a method of increasing glucuronidation of bilirubin in a subject, comprising administering to the subject an amount of chrysin effective to increase the glucuronidation of bilirubin. A method of increasing the expression of UDP-glucuronosyltransferase in a subject is provided, comprising administering to the subject an amount of chrysin effective to increase the UDP-glucuronosyltransferase. Upregulation of the expression of UDP-glucuronosyltransferase levels is expected to be beneficial in a number of areas: 1) increased detoxification of ingested carcinogens, such as the cooked-food mutagens (chrysin is an aromatase inhibitor in cells); 2) decreasing the conversion of androgens to estrogens, potentially building muscle mass or for prevention of breast cancer in women. In the method of upregulating UGT, UDP-glucuronosyltransferase can be a UGT1A isoform. A method of treating colon cancer is provided, comprising administering an effective amount of a flavone, whereby the administration of the flavone treats the colon cancer. |
