摘要 |
A pyrrolopyridazine derivative having formula (I) or a pharmaceutically acceptable salt thereof: <CHEM> Äwherein, R<1> is a C2-C6 alkenyl group, a halogeno C2-C6 alkenyl group, a C3-C7 cycloalkyl group which may be optionally substituted or a C3-C7 cycloalkyl- C1-C6 alkyl group which may be optionally substituted; R<2> is a C1-C6 alkyl group; R<3> is a hydroxymethyl group, a C2-C6 aliphatic acyloxymethyl group, a C6-C10 arylcarbonyloxymethyl group which may be optionally substituted, a C1-C6 alkoxycarbonyloxymethyl group, a formyl group, a carboxyl group, a C1-C6 alkoxycarbonyl group or a C6-C10 aryloxycarbonyl group which may be optionally substituted; R<4> is a C6-C10 aryl group which may be optionally substituted; A is an imino group, an oxygen atom or a sulfur atomÜ. ÄEffectÜ The pyrrolopyridazine derivatives of the present invention exhibit excellent gastric acid secretory inhibition activity and gastric mucous membrane protection activity etc. are useful as a medicament, preferably as a medicament for prevention or treatment of ulcerative disease. |