发明名称 |
CARBAPENEM DERIVATIVES SUBSTITUTED WITH IMIDAZOLINE RING |
摘要 |
PURPOSE: Provided are novel 1-β-methylcarbapenem derivatives substituted by pyrrolidine containing imidazoline ring which are strong antibiotics against resistant bacteria. CONSTITUTION: The compound is represented by chemical formula 1, where R is C1-6 low alkyl, aryl and benzyl group which are substituted by one or more groups from hydrogen, hydroxy, amine, sulfonyl and aminosulfonyl group. The process of preparing the compound consists of: converting diazoazetidione compound, chemical formula 2, to two ring keto ester under rhodium acetate catalyst and reacting at 0-5deg.C with diphenylchlorophosphate under base such as diisopropylethylamine; reacting the resultant with thiol derivative of chemical formula 3, and eliminating allyl group from the product by reacting with tributyltinhydride under tetrakisphosphine palladium(0) catalyst at room temp. for 2 hours. After reactions, distilled water is added to extract the water layer and it is freeze dried to get the final compound.
|
申请公布号 |
KR20010077072(A) |
申请公布日期 |
2001.08.17 |
申请号 |
KR20000004630 |
申请日期 |
2000.01.31 |
申请人 |
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY |
发明人 |
CHO, JEONG HYEOK;LEE, CHANG SIK;LEE, GI SU;LEE, IN GYU;LEE, SUK JA;OH, CHANG HYEON |
分类号 |
C07D477/20;(IPC1-7):C07D477/20 |
主分类号 |
C07D477/20 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|