发明名称 |
TNF- .ALPHA. INHIBITORS |
摘要 |
TNF- inhibitors containing at least one compound selected from among serivastatin, atorvastatin, simvastatin, pravastatin, itavastatin and (+)- (3R,5S)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N- methanesulfonylamino)pyrimidin-5-yl]-3,5-dihydroxy-6(E)-heptenoic acid and salts thereof which have sufficiently favorable properties as drugs, for example, exhibiting excellent preventive and therapeutic effects on TNF- .alpha.-associated diseases such as inflammatory diseases without showing an y side effects.
|
申请公布号 |
CA2399396(A1) |
申请公布日期 |
2001.08.16 |
申请号 |
CA20012399396 |
申请日期 |
2001.02.08 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
NARUO, KEN-ICHI;IKEYA, KAZUAKI;SUGIYAMA, YASUO;ODAKA, HIROYUKI;FUNATSU, MASAMI;SUZUKI, YOSHIHARU |
分类号 |
A61K31/22;A61K31/366;A61K31/40;A61K31/4418;A61K31/4709;A61K31/505;A61P9/04;A61P9/10;A61P11/00;A61P11/06;A61P13/10;A61P13/12;A61P19/02;A61P25/16;A61P25/28;A61P29/00;A61P31/04;A61P31/12;A61P37/02;A61P43/00;(IPC1-7):A61K31/22;A61K31/405;A61K31/440 |
主分类号 |
A61K31/22 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|