BENZO[<i>b</i>] THIOPHENE SULFONAMIDE-1, 1-DIOXIDE DERIVATIVES AND THEIR USE AS ANTINEOPLASTIC AGENTS

摘要

Compounds of formula (I) or (II) wherein: n is 1 or 2; R4 and R5 each represents hydrogen or C1-C3 alkyl; and each R may be in position 4, 5, 6, or 7 of the benzothiophene ring and independently represents hydrogen; a halogen; C1-C3 alkyl; or a group -SO2Y, in whch Y represents a group -NR1R2, a group -NHCOOR3, -NHCONH2 or a group -NHCONHR3 in which R1 and R2 are independently hydrogen, C1-C3 alkyl or aryl, and R3 is C1-C3 alkyl or aryl; with the proviso that one and only one R represents a group -SO2Y; are useful in the treatment of cancerous tumours.