发明名称 |
SPECIFIC MONOCLONAL ANTIBODY AGAINST TERBINAFINE |
摘要 |
The invention concerns monoclonal antibodies to terbinafine in free base or salt form, immunogenic conjugates suitable for preparing them, hybridoma capable of producing them, and corresponding assay kits. The antibodies can be prepared by administering to an appropriate animal an immunogenic conjugate of a suitable derivative of terbinafine covalently linked to an immunogen, recovering antibody-producing cells sensitized to the conjugate, immortalizing the antibody-producing cells, selecting a resultant immortalized cell line, and recovering the resultant antibodies therefrom. They are indicated for use in particular in the measurement of terbinafine tissue concentration and distribution in bodily fluids or compartments, especially nails.
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申请公布号 |
WO0159458(A1) |
申请公布日期 |
2001.08.16 |
申请号 |
WO2001EP01535 |
申请日期 |
2001.02.12 |
申请人 |
NOVARTIS AG;NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.;DOROBEK, BIRGIT;NUSSBAUMER, PETER |
发明人 |
DOROBEK, BIRGIT;NUSSBAUMER, PETER |
分类号 |
G01N33/53;A61K47/48;C07K14/435;C07K16/18;C07K16/44;C12N5/10;C12N15/02;C12P21/08;(IPC1-7):G01N33/577;C12N5/20 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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