Conjugates exhibiting IL-10 activity comprising (i) a polypeptide which comprises an amino acid sequence that differs from that of human IL-10 in at least one amino acid residue selected from an introduced or removed amino acid residue comprising an attachment group for the non-polypeptide moiety of (ii), and (ii) a non-polypeptide moiety. The conjugates have increased half-life as compared to hIL-10 and may be used for treatment of, e.g., inflammatory diseases.
申请公布号
WO0158950(A1)
申请公布日期
2001.08.16
申请号
WO2001DK00091
申请日期
2001.02.09
申请人
MAXYGEN APS;HANSEN, CHRISTIAN, KARSTEN;ANDERSEN, KIM, VILBOUR