| 摘要 |
<p>A hydrophobic hollow fiber membrane filter (10) defining a bundle of hydrophobic hollow fiber membranes (42) disposed within the interior chamber (34) is disclosed. The membranes (42) are in fluid communication with a recirculating bioreactor system wherein soluable carbon dioxide may be removed from the living solution (60) by applying a vacuum (72) to the device. The hydrophobic hollow fiber membrane filter (10) may be installed in an external piping recirculation loop (66) where living solution (60) may be introduced via a mechanical pump into a cylindrical access channel (50, 52). A pH sensor (70) indicates the living solution in the tank has moved outside the pH set-point, a vacuum (72) is initiated and dissolved carbon dioxide may be removed across the hydrophobic filter (10) in the recirculation loop (66). A control circuit (68) initiates vacuum (72) on the vent filter (64) to remove carbon dioxide from the mixing tank (78) headspace.</p> |
