发明名称 |
METHOD FOR DIASTEREOSELECTIVE PREPARATION OF PIPERIDINES FUNCTIONALISED IN POSITIONS 2 AND 4 FOR USE AS SYNTHESIS INTERMEDIATES |
摘要 |
The invention concerns a method for preparing, with diastereoselective induction, a piperidine monosubstituted in position 4 and functionalised in position 2, comprising steps which consist in: (i) reacting the corresponding N-protected piperidine, monosubstituted in position 4 and non-functionalised in position 2, with a strong base so as to form the negatively charged corresponding carbanion in position 2; then (ii) reacting said carbanion with an electrophilic reagent, with a volume less than 80 ANGSTROM <3> or more than 100 ANGSTROM <3>. |
申请公布号 |
WO0158872(A1) |
申请公布日期 |
2001.08.16 |
申请号 |
WO2001FR00370 |
申请日期 |
2001.02.08 |
申请人 |
RHODIA CHIMIE;COSSY, JANINE;BELLOTI, DAMIEN;DESMURS, JEAN-ROGER |
发明人 |
COSSY, JANINE;BELLOTI, DAMIEN;DESMURS, JEAN-ROGER |
分类号 |
A61P7/02;C07D211/60 |
主分类号 |
A61P7/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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