发明名称 |
ANDROGEN RECEPTOR SUPPRESSORS IN THE THERAPY AND DIAGNOSIS OF PROSTATE CANCER, ALOPECIA AND OTHER HYPER-ANDROGENIC SYNDROMES |
摘要 |
Substituted phenylalanines are provided comprising an hydantoin, urea or 2- hydroxyl, 2-methylpropionyl group, dimers thereof and alkyl, polyfluoroamido and haloarylamino derivatives thereof, as well as radiolabeled derivatives thereof. The compounds bind specifically to the androgen receptor and find u se in indications associated with the androgen receptor, such as cell hyperplas ia dependent on androgens, hirsutism, acne and androgenetic alopecia.
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申请公布号 |
CA2400185(A1) |
申请公布日期 |
2001.08.16 |
申请号 |
CA20012400185 |
申请日期 |
2001.02.09 |
申请人 |
BIOPHYSICA, INC. |
发明人 |
SELIGSON, ALLEN;DOUGLASS, JAMES GORDON III;CAMPION, BRIAN;BROWN, JASON W.;SOVAK, MILOS |
分类号 |
C07D295/10;A61K31/165;A61K31/167;A61K31/277;A61K31/40;A61K31/417;A61P5/00;A61P5/28;A61P17/10;A61P17/14;A61P35/00;C07C231/02;C07C237/04;C07C237/22;C07C255/56;C07C255/60;C07C275/30;C07C317/46;C07C323/60;C07C335/08;C07C335/16;C07C335/22;C07D207/40;C07D207/408;C07D233/02;C07D233/72;C07D233/86;C07D233/88;(IPC1-7):C07C237/22 |
主分类号 |
C07D295/10 |
代理机构 |
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地址 |
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