摘要 |
A pyrrolopyridazine compound represented by the general formula (I) or a pharmacologically acceptable salt thereof. (In the formula, R1 is C2-6 alkenyl, C2-6 halogenoalkenyl, optionally substituted C3-7 cycloalkyl, or optionally substituted C1-6 alkyl substituted by C3-7 cycloalkyl; R2 is C1-6 alkyl; R3 is hydroxymethyl, C2-6 aliphatic acyloxymethyl, optionally substituted (C6-10 aryl)carbonyloxymethyl, (C1-6 alkoxy)carbonyloxymethyl, formyl, carboxy, (C1-6 alkoxy)carbonyl, or optionally substituted (C6-10 aryl)oxycarbonyl; R4 is optionally substituted C6-10 aryl; and A is imino, oxygen, or sulfur.) The pyrrolopyridazine compound is highly effective in inhibiting the secretion of gastric hydrochloric acid, protecting the gastri c mucosa, and the like. It is useful as a medicine, especially a preventive/remedy for ulcerative diseases.
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申请人 |
SANKYO COMPANY, LIMITED;UBE INDUSTRIES, LTD. |
发明人 |
IWABUCHI, HARUO;FUJIWARA, HIROSHI;MATSUNOBU, KEIJI;HAGIHARA, MASAHIKO;SHIBAKAWA, NOBUHIKO |