The present invention is directed to an article which has a pattern of biologically active molecules stably adsorbed directly onto a polymeric substrate. The present invention also provides methods for preparing a pattern of biologically active molecules on the surface of a polymeric substrate, which include exposing a polymeric substrate to conditions that increase the polarity of a surface of the polymeric substrate, and contacting that surface with a stamp that includes a micron-sized pattern coated with biologically active molecules. The present invention also provides a method to spatially modulate the growth of a cell which includes contacting a cell with an article of the present invention for a time and under conditions sufficient to adhere the cell to the biologically active molecules and to grow the cell along the micron-sized pattern of biologically active molecules on the polymeric substrate.
申请公布号
WO0158502(A1)
申请公布日期
2001.08.16
申请号
WO2001US04842
申请日期
2001.02.12
申请人
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY;UHRICH, KATHRYN, E.;BUETTNER, HELEN;SCHMALENBERG, KRISTINE