PROCESS FOR SELECTIVELY PRODUCING 1-PHOSPHORYLATED SUGAR DERIVATIVE ANOMER AND PROCESS FOR PRODUCING NUCLEOSIDE

摘要

A mixture of 1-phosphorylated sugar derivative anomers is phosphorolyzed and isomerized to thereby crystallize one of the anomers. Thus, the equilibrium is shifted and a desired isomer alone is selectively produced. From the 1-phosphorylated sugar derivative thus obtained and a base, a nucleoside is produced at a high stereoselectivity and a high yield under the action of a nucleoside phosphorylase. Thus, a process for anomer-selectively producing a 1-phosphorylated sugar derivative and a process for producing a nucleoside are provided.