摘要 |
Novel human protein C derivatives are described. These derivatives have increased anti-coagulation activity, resistance to serpin inactivation, and increased sensitivity to thrombin activation compared to wild-type protein C and retain the biological activity of the wild-type human protein C. These derivatives will require either less frequent administration and/or smaller dosage than wild-type human protein C in the treatment of acute coronary syndromes, vascular occlusive disorders, hypercoagulable states, thrombotic disorders and disease states predisposing to thrombosis.
|
申请人 |
ELI LILLY AND COMPANY;GERLITZ, BRUCE, EDWARD;GRINNELL, BRIAN, WILLIAM;JONES, BRYAN, EDWARD |
发明人 |
GERLITZ, BRUCE, EDWARD;GRINNELL, BRIAN, WILLIAM;JONES, BRYAN, EDWARD |