发明名称 |
METHOD FOR THE PREPARATION OF (S)-2-ACETYLTHIO-3-PHENYLPROPIONIC ACID |
摘要 |
Method for the preparation of (S)-2-acetylthio-3-phenylpropionic acid, wherein (R)-2-bromo-3-phenylpropionic acid is contacted with thioacetic acid and an organic base, for example triethylamine. Preferably the base is metered to a mixture of (R)-2-bromo-3-phenylpropionic acid and thioacetic acid at a temperature between -10 DEG C and +30 DEG C. (R)-2-bromo-3-phenylpropionic acid is preferably prepared starting from D-phenylalanine, sodium nitrite, HBr and a bromide salt, in an aqueous solution at a temperature between -10 and 30 DEG C, and subsequently without isolation converted into (S)-2-acetylthio-3-phenylpropionic acid. The (S)-2-acetylthio-3-phenylpropionic acid obtained can be used in the preparation of pharmaceuticals, in particular ACE inhibitor such as Omapatrilat.
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申请公布号 |
WO0158865(A1) |
申请公布日期 |
2001.08.16 |
申请号 |
WO2001NL00078 |
申请日期 |
2001.02.02 |
申请人 |
DSM N.V.;LOMMEN, FRANCISCUS, ALPHONS, MARIE;KOLLER, HELMUT;SCHERUBL, HERBERT |
发明人 |
LOMMEN, FRANCISCUS, ALPHONS, MARIE;KOLLER, HELMUT;SCHERUBL, HERBERT |
分类号 |
C07C51/363;C07C327/32;(IPC1-7):C07C327/32;C07D513/04 |
主分类号 |
C07C51/363 |
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