摘要 |
TNF- inhibitors containing at least one compound selected from among serivastatin, atorvastatin, simvastatin, pravastatin, itavastatin and (+)-(3R,5S)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino)pyrimidin-5-yl]-3,5-dihydroxy-6(E)-heptenoic acid and salts thereof which have sufficiently favorable properties as drugs, for example, exhibiting excellent preventive and therapeutic effects on TNF- alpha -associated diseases such as inflammatory diseases without showing any side effects.
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申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD.;SUGIYAMA, YASUO;ODAKA, HIROYUKI;NARUO, KEN-ICHI;FUNATSU, MASAMI;IKEYA, KAZUAKI;SUZUKI, YOSHIHARU |
发明人 |
SUGIYAMA, YASUO;ODAKA, HIROYUKI;NARUO, KEN-ICHI;FUNATSU, MASAMI;IKEYA, KAZUAKI;SUZUKI, YOSHIHARU |