VERFAHREN ZUR BESTIMMUNG VON WIRKSUBSTANZEN

摘要

The invention relates to a method for determining active agents which influence the covalent bonding of polypeptides on the surface of gram-positive bacteria according to the following steps: a) preparation of a gram-positive bacteria sample having or forming at least one enzymatic reporter substance which is or can be covalently bonded with the surface of the gram-positive bacteria. The sample having at least one reporter substance which is not covalently bonded on the surface of the gram-positive bacteria comprises an additional enzymatic activity as a covalent bonding on the surface of gram-positive bacteria; b) bringing the sample into contact with a possible active agent and; c) determining the enzymatic activity of the reporter substance of the sample gram-positive bacteria.