发明名称 |
Humanized anti-ccr2 antibodies and methods of use therefor |
摘要 |
The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor (2) (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods. |
申请公布号 |
AU3327701(A) |
申请公布日期 |
2001.08.14 |
申请号 |
AU20010033277 |
申请日期 |
2001.02.02 |
申请人 |
MILLENNIUM PHARMACEUTICALS, INC. |
发明人 |
GREGORY J LAROSA;CHRISTOPHER HORVATH;WALTER NEWMAN;S. TARRAN JONES;SIOBHAN O'BRIEN;THERESA O'KEEFE |
分类号 |
C12N15/09;A61K38/00;A61K39/395;A61P9/00;A61P9/10;A61P19/02;A61P25/00;A61P29/00;A61P31/18;A61P37/06;A61P43/00;C07K14/715;C07K16/28;C07K16/46;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/13;C12P21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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