发明名称 Method of determining a functional linker for fusing globin subunts
摘要 A functional linker for a polypeptide in which two alpha or beta globin-like domains are genetically fused is determined by screening a library of genetically fused polypeptides, in which the linker region is varied, for the ability to participate in the formation of hemoglobin-like protein, as measured by the protein's response to carbon monoxide. In a preferred embodiment, cells expressing the protein turn red as a result of carbon monoxide pressure.
申请公布号 US6274331(B1) 申请公布日期 2001.08.14
申请号 US19950444915 申请日期 1995.05.19
申请人 SOMATOGEN, INC. 发明人 LOOKER DOUGLAS L.;STETLER GARY L.
分类号 A61K38/16;A61K38/00;A61K47/48;A61P7/08;C07K;C07K1/113;C07K14/805;C12N15/00;C12N15/09;C12N15/12;C12N15/81;C12P21/02;C12R1/19;C12R1/91;(IPC1-7):G01N33/53 主分类号 A61K38/16
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