| 摘要 |
<p>Blood cholesterol levels are correlated with production of amyloid B protein (AB), and risk of developing AD. Increasing HDL-cholesterol levels, HDL-apoA-I levels, or HDL function, decrease production of AB. Compounds which function as HDL include synthetic HDL which contains lipid such as phosphatidyl choline, phosphatidyl serine, phosphatidyl ethanolamine. Compounds which enhance HDL function include HDL associated proteins such as apo A1 or variants, reverse lipid transport peptides, apoE, enzymes associated with HDL such as paraoxonase, and LCAT, preferably, formulated in combination with liposomes or emulsions. These compositions can also be administered with compounds that increase HDL levels specifically, and thereby improve the HDL cholesterol to total cholesterol ratio or the apoA-I to total cholesterol ratio, and/or with compositions which are effective to improve the HDL or apoA-I to total blood cholesterol levels. Alternatively, cholesteryl ester transfer protein inhibitors can be used to treat Alzheimer's.</p> |
