| 摘要 |
<p>Integrin expression inhibitors and remedies for arteriosclerosis, psoriasis, cancer, retinal angiogenesis, diabetic retinitis or inflammatory diseases, anticoagulant agents and cancerous metastasis inhibitors based on the integrin inhibitory effect. Namely, integrin expression inhibitors containing as the active ingredient sulfonamide compounds represented by the following general formula (I), pharmacologically acceptable salts thereof or hydrates of the same wherein B represents optionally substituted C6-10 aryl or 6- to 10-membered heteroaryl wherein the ring may be partly saturated; K represents a single bond, -CH=CH- or -(CR4bR5b)mb- (wherein R?4b and R5b¿ may be the same or different and each represents hydrogen or C¿1-4? alkyl; and m?b¿ represents an integer of 1 or 2); R1 represents hydrogen or C¿1-6? alkyl; Z represents a single bond or CO-NH-; and R represents optionally substituted C6-10 aryl or 6- to 10-membered heteroaryl wherein the ring may be partly saturated.</p> |
