METHODS AND MATERIALS RELATING TO MATRIX METALLOPROTEASE-LIKE POLYPEPTIDES AND POLYNUCLEOTIDES

摘要

The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted MMP-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from fetal skin (Invitrogen) (Hyseq clone identification number 18066640 (SEQ ID NO: 1), Hyseq clone identification number 18059666 (SEQ ID NO: 4), and Hyseq clone identification number 18091026 (SEQ ID NO: 5)), and from a cDNA library from mixed tissues (Invitrogen, Clontech, and Biochain) (Hyseq clone identification number 32288188 (SEQ ID NO: 3)). Other aspects of the invention include vectors containing processes for producing novel human secreted MMP-like polypeptides, and antibodies specific for such polypeptides.