METHODS AND MATERIALS RELATING TO NEURONAL GUIDANCE MOLECULE-LIKE (NGM-LIKE) POLYPEPTIDES AND POLYNUCLEOTIDES

摘要

The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human secreted NGM-like polypeptides. These polynucleotides comprise nucleic acid sequences isolated from at least cDNA libraries prepared from adult spleen mRNA (GIBCO) (Hyseq clone identification numbers 3073928 (SEQ ID NO: 1), and from infant brain mRNA (Columbia University) (Hyseq clone identification number 6346549) (SEQ ID NO: 18). Other aspects of the invention include vectors containing processes for producing novel human secreted NGM-like polypeptides, and antibodies specific for such polypeptides.