| 摘要 |
<p>The present invention relates to a basal cell carcinoma (BCC) model system by pro-viding a transgenic non-human animal comprising a diploid genome comprising a transgene containing a nucleic acid sequence encoding GLI-1 or a derivative thereof. The transgene is inserted in such a way that GLI-1 or a derivative thereof is overexpressed in said animal. Preferably, the protein is overexpressed in the skin of the animal. The invention also provides a method for screening a drug candidate and evaluating whether it affects basal cell carcinoma.</p> |
