MUCIN-1 DERIVED ANTIGENS AND THEIR USE IN IMMUNOTHERAPY

摘要

Peptides and polypeptides capable of eliciting the immune response are disclosed which comprise an amino acid sequence substantially corresponding to that of an epitope of the non-VNTR, non-leader region of mucin. The peptides or polypeptides are useful themselves, or in the form of fusion proteins or conjugate compounds with carbohydrate polymers, in the prevention or treatment of disease states, particularly carcinomas such as adenocarcinomas. DNA vaccines and uses of the peptides and polypeptides for pulsing dentritic cells for in vivo transfer are also disclosed.