| 摘要 |
<p>Compounds having an Rho kinase inhibitory activity. These compounds include the compound of general formula (I): Het-X-Z, pharmaceutically acceptable salts thereof and solvates of the same, wherein Het represents a monocyclic or dicyclic heterocycle group containing at least one nitrogen atom (for example, pyridyl, phthalimido); X represents (i) an -NH-C(=O)-NH-Q1- group, (ii) an -NH-C(=O)-Q2- group, etc. (wherein Q1 and Q2 represent each a bond, alkylene or alkenylene); and Z represents hydrogen, halogeno, a monocyclic, dicyclic or tricyclic carbon cycle or heterocycle, etc. (for example, optionally substituted phenyl).</p> |
