发明名称 |
3,5-bis-(Trifluoromethyl)-benzoyl chloride preparation in high yield in 4 stages from readily available 3,5-dimethyl-benzoic acid, for use as intermediate for drugs, pesticides or photoresistant |
摘要 |
Preparation of 3,5-bis-(trifluoromethyl)-benzoyl chlorides (I) involves converting a 3,5-dimethyl-benzoic acid (V) into the acid chloride (IV), subjecting the side-chains to radical chlorination, fluorinating with anhydrous hydrogen fluoride and/or antimony pentafluoride to give a 3,5-bis-(trifluoromethyl)-benzoyl fluoride and reacting with silicon tetrachloride in presence of another Lewis acid. Preparation of 3,5-bis-(trifluoromethyl)-benzoyl chlorides of formula (I) involves: (1) converting a 3,5-dimethyl-benzoic acid of formula (V) into the corresponding acid chloride of formula (IV); (2) subjecting the side-chains to complete radical chlorination to give a 3,5-bis-(trichloromethyl)-benzoyl chloride of formula (III); (3) fluorinating with anhydrous hydrogen fluoride and/or antimony pentafluoride to give a 3,5-bis-(trifluoromethyl)-benzoyl fluoride of formula (II); and (4) reacting with silicon tetrachloride in presence of another Lewis acid. [Image] X : H, F or Cl. Independent claims are included for the intermediates (III; X = F or Cl) and (IV; X = F or Cl) as new compounds.
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申请公布号 |
DE10004717(A1) |
申请公布日期 |
2001.08.09 |
申请号 |
DE2000104717 |
申请日期 |
2000.02.03 |
申请人 |
BAYER AG |
发明人 |
MARHOLD, ALBRECHT;STOELTING, JOERN |
分类号 |
C07C51/58;C07B61/00;C07C51/60;C07C51/62;C07C63/00;C07C63/70;(IPC1-7):C07C63/70 |
主分类号 |
C07C51/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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