摘要 |
Disclosed is a method of inhibiting biosynthesis or bioactivity of endogenous steroid sex hormones in both men and women involving the administration of a combination of phytosterol(s) and phytoestrogen(s) to inhibit enzymatic activity in the steroidogenic biosynthetic pathway that converts steroid progestins and androgens to more potent steroidal hormones, like estradiol and dihydrotestosterone. Also disclosed is a pharmaceutical composition useful for inhibiting biosynthesis or bioactivity of endogenous steroid sex hormones in humans. The pharmaceutical composition is formulated in a delivery system to deliver a dose of 50 to 250 mg of a phytosterol(s), such as campesterol, sitosterol, fucosterol, stigmasterol, stigmastanol, or stigmastadienone, or a derivative or conjugate of any of these, and 20 to 150 mg of a phytoestrogen(s), such as a lignan, isoflavone, flavone, or coumestan compound(s).
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