发明名称 |
CONTROLLED RELEASE ORAL PREPARATIONS OF ESCULETIN AND ITS DERIVATIVES |
摘要 |
<p>The present invention relates to an oral preparation of esculetin with controlled release. The oral preparation of esculetin with controlled release of the present invention comprises a gel-forming polymer base, preferably hydroxypropylmethylcellulose. The preparation may be coated with an enteric polymer base such as hydroxypropylmethylcellulose acetate succinate to thereby enhance solubility in the intestines. When orally administered, the preparation can continuously release esculetin. Thus, the administration frequency and dose can be reduced and a therapeutic effect on arthropathy can be established.</p> |
申请公布号 |
EP1121931(A1) |
申请公布日期 |
2001.08.08 |
申请号 |
EP19990969947 |
申请日期 |
1999.10.04 |
申请人 |
KUREHA CHEMICAL INDUSTRY CO., LTD. |
发明人 |
YAMAGUCHI, IWAO;ONO, SAICHI;CHIBA, TADAHIKO |
分类号 |
C07D311/16;A61K9/20;A61K9/22;A61K9/28;A61K9/48;A61K9/50;A61K9/52;A61K9/62;A61K31/00;A61K31/35;A61K31/352;A61K31/37;A61K47/38;A61P19/00;A61P19/02;A61P29/00;(IPC1-7):A61K31/37;A61K9/24;A61K47/32 |
主分类号 |
C07D311/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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