发明名称 PRODRUGS OF PHOSPHOROUS-CONTAINING PHARMACEUTICALS
摘要 Pharmaceutical compounds with the formula: Drug-P(=O)-O-Linker(-R2')k-R2 where Drug-P(=O)-O- is the residue of a drug comprising a phosphonate, phosphinate or phosphoryl function, such as alendronate or foscarnet, R2 and R2' (if present) are independently the acyl residue of an aliphatic amino acid; Linker is an at least difunctional moiety comprising a first function ester-bonded to the phosphonate, phosphinate or phosphoryl function spaced from a second function ester-bonded to R2; and k is 1 or zero; have enhanced bioavailability or other pharmacokinetic performance relative to the parent drug.
申请公布号 EP1121366(A1) 申请公布日期 2001.08.08
申请号 EP19990921327 申请日期 1999.03.30
申请人 MEDIVIR AB 发明人 ZHOU, XIAO-XIONG;JOHANSSON, NILS, GUNNAR;WAEHLING, HORST;SUND, CHRISTIAN;WALLBERG, HANS;SALVADOR, LOURDES;LINDSTROEM, STEFAN
分类号 A61K31/662;A61K31/675;A61P3/14;A61P19/02;A61P19/08;A61P19/10;A61P29/00;A61P37/02;C07D;C07D473/32;C07F9/38;C07F9/40;C07F9/58;C07H19/06;C07H19/16 主分类号 A61K31/662
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