Method for production of a test surface for use in optical detection of a biological binding event

摘要

A process for producing multilayer thin film elements useful in a wide variety of optical detection and assay methods and systems is disclosed. Also the elements, made by said process, exhibit improved test surfaces whose multilayers include at least one light reflective layer or substrate, a barrier layer attached thereto, and a reactive layer thereover having a measureable coating thickness different from the interactive analyte of interest. The elements find utility in numberous thin film assays systems including those involving chemical, immunological and optical and non-optical determinations and particular in ellipsometric immunoassay.