发明名称 Human adenylate cyclase IX and use therefor
摘要 There is provided a novel adenylate cyclase enzyme, the nucleotide sequence of which is set out in SEQ ID No: 98. The activity of the adenylate cyclase is uniquely regulated by calcineurin, a protein phosphatase. The calcineurin binding site has been identified at amino acids 503 to 610 of the novel adenylate cyclase. Regulation of the novel adenylate cycalse may be useful in treating certain disorders. Suitable regulators include agents which bind to the 503-610 amino acid site and include calcineurin, its activators, inhibitors and competitors and antibodies specific to that site. Specific disorders include neurological disorders such as Parkinsons' disease, cardiovascular disorders such as angina pectoris and tumours, especially ovarian tumours. <IMAGE>
申请公布号 EP1097991(A3) 申请公布日期 2001.08.08
申请号 EP20000308130 申请日期 2000.09.18
申请人 MEDICAL RESEARCH COUNCIL 发明人 ANTONI, FERENC;PATERSON, JANICE M.
分类号 A61K38/00;A61K38/13;A61K38/16;A61K45/06;A61K48/00;A61K49/00;C07K16/40;C12N9/88;C12N15/60 主分类号 A61K38/00
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