| 摘要 |
PROBLEM TO BE SOLVED: To provide an analgesic having ORL1-receptor agonist activity. SOLUTION: The objective compound is expressed by general formula (I) or its pharmacologically permissible salt [R1 is an unsubstituted or substituted cycloalkyl or cycloalkenyl or the like; A is an unsubstituted alkyl or alkenyl, a hydroxyalkyl, an alkoxy-(C=O), an unsubstituted or substituted aryl, an aromatic heterocyclic group or the like; M is one covalent bond, O, S, NH or the like; Y is a bicyclic carbon ring, a bicyclic heterocyclic group, a spiro-carbon ring, a spiro-heterocyclic group or the like; Z1, Z2, Z3 and Z4 are each H or the like].
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