VACCINE COMPOSITION FOR ELICITING AN IMMUNE RESPONSE AGAINST N-GLYCOLYLATED GANGLIOSIDES AND ITS USE FOR CANCER TREATMENT

摘要

The present invention relates to the active specific immunotherapy of cancer and among other things provides a vaccine composition for producing or increasing the antibody immune response against N-glycolylated gangliosides, especially N-glycolyl GM3 (NGcGM3), which can be used for the prevention and treatment of cancer. The vaccine composition comprises an adequate amount of N-glycolylated ganglioside and/or its derivatives and/or its corresponding oligosaccharide, coupled non covalently or covalently to adequate protein or protein complex carriers depending on the case, and containing additionally, any appropriate adjuvant.