发明名称 |
Antisense oligonucleotides for mitogen-activated protein kinases as therapy for cancer |
摘要 |
A method is disclosed for inhibiting malignant neoplastic growth of epithelial or endothelial cells in a mammal by administering to the mammal an effective amount of an oligonucleotide complementary to at least a portion of mRNA for ERK-1 or ERK-2 that is overexpressed in the mammal. The antisense oligonucleotides are administered to the mammal as a dosage unit. A method of identifying and monitoring potentially malignant neoplastic cell growth in a mammal is also disclosed.
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申请公布号 |
US6271210(B1) |
申请公布日期 |
2001.08.07 |
申请号 |
US19990412289 |
申请日期 |
1999.10.05 |
申请人 |
THE RESEARCH FOUNDATION OF SUNY |
发明人 |
SIVARAMAN VIMALA S.;WANG HSIEN-YU;MALBON CRAIG C. |
分类号 |
C12N15/09;A61K31/711;A61K38/00;A61K48/00;A61P35/00;C12N15/113;C12Q1/68;(IPC1-7):A61K48/00;C07H21/04;C12N15/85 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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