| 摘要 |
PROBLEM TO BE SOLVED: To provide a new compound having a sphingomyelinase antagonism. SOLUTION: This compound is a derivative of sphingosine or its pharmaceutically permissible salt expressed by general formula I [R1 is H, a 2-20C alkanoyl, benzoyl or the like, R2 is H, a 1-8C alkyl, -(CH2)nR5 (R5 is hydroxyl, an amino, a pyridyl, a pyrazyl, a morpholinyl, a thiazolyl, a tetrazolyl or the like, n is an integer of 0-5) or SOmR6 (R6 is phenyl or a substituted phenyl substituted with a halogen, a 1-5C alkyl, hydroxyl, an amino, an ureide group or the like, m is 0, 1 or 2.), Z is NR7 (R7 is H, hydroxyl or a 1-5C alkyl), Y is oxygen or NR8 (R8 is H or hydroxyl or a 1-5C alkyl), W is oxygen or sulfur, k is an integer of 1-20]. |
