发明名称 |
Methods and compositions for the detection of bacterial endotoxins |
摘要 |
The invention provides methods and compositions for the detection and/or quantification of bacterial endotoxins. In particular, provided herein is an inexpensive and reproducible method for producing an improved amebocyte lysate preparation having reduced Factor G activity. Provided also is an endotoxin-specific amebocyte lysate preparation produced by such a method. In addition, the invention provides methods and compositions for enhancing the sensitivity to endotoxins of amebocyte lysate preparations having reducing Factor G activity. In particular, the sensitivity of such amebocyte lysate preparations to endotoxins can be enhanced by the addition of exogenous (1->3) beta-D-glucan.
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申请公布号 |
US6270982(B1) |
申请公布日期 |
2001.08.07 |
申请号 |
US19970947584 |
申请日期 |
1997.10.09 |
申请人 |
CHARLES RIVER LABORATORIES |
发明人 |
JORDAN FOSTER T.;CHIANG HUI-TI;COOPER JAMES F.;WAINWRIGHT NORMAN R. |
分类号 |
G01N33/579;(IPC1-7):G01N33/554;G01N33/53;A61K39/02;A61K45/00 |
主分类号 |
G01N33/579 |
代理机构 |
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主权项 |
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地址 |
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