| 发明名称 |
Modified factor VIII cDNA |
| 摘要 |
A modified Factor VIII cDNA is described comprising deletion of the B-domain and insertion of at least one truncated Factor IX intron 1 in the Factor VIII cDNA. The modified Factor VIII cDNA may be used for the production of a high yield of Factor VIII in vitro. The modified Factor VIII cDNA may be incorporated into a vector for gene therapy.
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| 申请公布号 |
US6271025(B1) |
申请公布日期 |
2001.08.07 |
| 申请号 |
US20000526935 |
申请日期 |
2000.03.16 |
| 申请人 |
AVENTIS BEHRING GMBH |
发明人 |
NéGRIER CLAUDE;PLANTIER JEAN LUC |
| 分类号 |
C12N15/09;A61K48/00;A61P7/04;C07K14/755;C12N5/10;C12N15/12;C12P21/02;C12R1/91;(IPC1-7):C12N15/00;C12N15/63;C12P21/06;C07H21/04 |
主分类号 |
C12N15/09 |
| 代理机构 |
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