发明名称 |
INDOLE DERIVATIVES |
摘要 |
Disclosed are compounds of formula I (See formula I) wherein R1 is a hydrogen atom, a C1-C6 alkyl group, benzyl or an indolyl carbonyl group, R2 is a saturated or unsaturated 5- to 8-membered heterocyclic group containing as a hetero atom one or more nitrogen atoms, the heterocyclic group is optionally substituted at an N or C atom by a C1-C6 alkyl or aralkyl group, n is an integer of 1 to 5 and one or more hydrogen atoms, in an alkylene chain -(CH2)n- are optionally substituted by a C1-C6 alkyl, phenyl, benzyl and/or hydroxyl group, physiologically acceptable salts and quaternary ammonium salts thereof. The compounds are selective antagonists of 5-HT3 receptors and are useful in the treatment of psychotic disorders, neurotic diseases, gastric stasis symptoms, gastrointestinal disorders, nausea and vomiting.
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申请公布号 |
CA2030051(C) |
申请公布日期 |
2001.08.07 |
申请号 |
CA19902030051 |
申请日期 |
1990.11.15 |
申请人 |
KIKUCHI, HARUHIKO;SATOH, HIROAKI;YANAI, MAKOTO;SUGURO, TOSHIO;HAGIHARA, KOICHIRO |
发明人 |
KIKUCHI, HARUHIKO;SATOH, HIROAKI;YANAI, MAKOTO;SUGURO, TOSHIO;HAGIHARA, KOICHIRO |
分类号 |
C07D209/42;C07D401/12;C07D403/12;C07D403/14;(IPC1-7):C07D401/12;C07D401/14;A61K31/395 |
主分类号 |
C07D209/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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