发明名称 |
TARGETING OF PEG ANTIBODY CONJUGATES TO ISLET CELLS |
摘要 |
A method for delaying onset of insulin dependent diabetes mellitus (IDDM) in an individual predisposed to developing the disease is disclosed. The method comprises administering a composition comprising an immunologically effective monoclonal antibody or fragment thereof against glutamic acid decarboxylase (GAD) coupled to a nonimmunogenic hydrophilic polymer that provides a hydration shell around the monoclonal antibody for inhibiting immune recognition thereof. Poly(ethylene glycol) is a preferred polymer. A method of reducing insulitis in an IDDM patient and a composition therefor are also described.
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申请公布号 |
US2001010820(A1) |
申请公布日期 |
2001.08.02 |
申请号 |
US19980222357 |
申请日期 |
1998.12.29 |
申请人 |
JACOBS HARVEY;KIM SUNG WAN;MENARD VIRGINIE |
发明人 |
JACOBS HARVEY;KIM SUNG WAN;MENARD VIRGINIE |
分类号 |
A61K39/395;A61K31/00;A61K38/00;A61K39/44;A61K47/48;A61P3/00;A61P3/10;C07K16/40;(IPC1-7):A61K39/395;A61K39/40;A61K39/42 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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