发明名称 |
SYNTHETIC GENES FOR ENHANCED EXPRESSION |
摘要 |
<p>A synthetic nucleic acid sequence is disclosed, comprising a non-naturally occurring polymer of nucleic acids, having a biological function encoded by the sequence and known from a starting nucleic acid sequence, and having a difference in sequence of at least about 5 % between the nucleic acids of the synthetic sequence and the starting sequence. The difference between the nucleic acid sequences results in a different free energy of folding for the synthetic sequence as compared to the starting sequence, such that the synthetic sequence would be expressed better in a selected heterologous host cell than the starting sequence would be if expressed in the same heterologous host cell.</p> |
申请公布号 |
WO0155342(A2) |
申请公布日期 |
2001.08.02 |
申请号 |
WO2001US03186 |
申请日期 |
2001.01.31 |
申请人 |
BIOCATALYTICS, INC. |
发明人 |
ROZZELL, DAVID, J., JR.;BUI, PETER;HUA, LING |
分类号 |
C07K14/21;C12N15/00;(IPC1-7):C12N/ |
主分类号 |
C07K14/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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