| 摘要 |
The present invention provides a matrix metalloproteinase inhibiting compound having structure (VIII) or a salt, an enantiomer, a diastereomer, a racemate, or a tautomer thereof. In other embodiments, the present invention provides a method of changing the conformation of a matrix metalloproteinase, a method of inhibiting a matrix metalloproteinase, and a method of treating osteoarthritis. |
| 申请人 |
G.D. SEARLE & CO.;STALLINGS, WILLIAM, C.;SHIEH, HUEY, S.;HOWARD, SUSAN, C.;DE CRECENZO, GARY, A.;MC DONALD, JOSEPH, J. |
发明人 |
STALLINGS, WILLIAM, C.;SHIEH, HUEY, S.;HOWARD, SUSAN, C.;DE CRECENZO, GARY, A.;MC DONALD, JOSEPH, J. |
