| 摘要 |
<p>A neural regeneration conduit (10) employing spiral geometry (17) is disclosed. The spiral geometry is produced by rolling a flat sheet into a cylinder. The conduit can contain a multiplicity of functional layers lining the lumen of the conduit, including a confluent layer of adherent Schwann cells (126). The conduit can produce a neurotrophic agent concentration gradient by virtue of neurotrophic agent-laden microspheres (24) arranged in a nonuniform pattern and embedded in a polymer hydrogen layer lining the lumen of the conduit.</p> |
