NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES

摘要

The present invention relates to novel respiratory system related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "respiratory system antigens", and the use of such respiratory system antigens for detecting disorders of the respiratory syste m, particularly the presence of cancer of respiratory system tissues and cancer metastases. More specifically, isolated respiratory system associated nuclei c acid molecules are provided encoding novel respiratory system associated polypeptides. Novel respiratory system polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, a nd recombinant and synthetic methods for producing human respiratory system associated polynucleotides and/or polypeptides. The invention further relate s to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the respiratory system, including cancer of respiratory system tissues, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting theproduction and function of the polypeptides o f the present invention.