发明名称 |
Adeno-associated vector compositions for expression of factor VIII |
摘要 |
One form of a composition has two types of recombinant adeno-associated virus. The first type encodes a portion of Factor VIII operably linked to an expression control element; and the second type encodes a different portion of Factor VIII operably linked to an expression control element. The first and second nucleotide sequences collectively encode a functional Factor VIII protein. Another form of the composition is a recombinant adeno-associated virus containing a nucleotide sequence encoding functional Factor VIII light or heavy chain operably linked to a tissue-specific promoter.
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申请公布号 |
US2001010815(A1) |
申请公布日期 |
2001.08.02 |
申请号 |
US20000740211 |
申请日期 |
2000.12.18 |
申请人 |
COUTO LINDA B.;COLOSI PETER C.;QIAN XIAOBING |
发明人 |
COUTO LINDA B.;COLOSI PETER C.;QIAN XIAOBING |
分类号 |
C12N15/09;A61K35/76;A61K38/27;A61K38/37;A61K38/43;A61K48/00;A61P7/04;C07K14/755;C12N5/10;C12N15/861;C12N15/864;(IPC1-7):A61K48/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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