METHOD FOR PREPARING MONO-, DI- AND TRICARBOXY CYCLODEXTRINS BY REGIOSELECTIVE OXIDATION IN POSITION 6 OF NATIVE alpha OR beta OR gamma CYCLODEXTRINS

摘要

The invention concerns a method for preparing mono-6-deoxy-6-carboxy and di-[6-deoxy-6-carboxy] and tri-[6-deoxy-6-carboxy]-cyclomalto-hexaose or -heptaose or -octahose. Said method consists in regioselective oxidation of one or several primary hydroxyls in position 6 of the glucopyranose units of an alpha or beta or gamma -cyclodextrin, in aqueous solution, with controlled basic pH, at a temperature less than 5 DEG C, in the presence of a TEMPO radical, of sodium bromide and sodium hypochlorite.