发明名称 |
METHOD FOR USING POTASSIUM CHANNEL ACTIVATION FOR DELIVERING A MEDICANT TO AN ABNORMAL BRAIN REGION AND/OR A MALIGNANT TUMOR |
摘要 |
Disclosed are methods of selectively delivering a medicant to an abnormal brain region and/or to a malignant tumor in a mammalian subject, including a human. A medicant is administered simultaneously or substantially simultaneously with a calcium- or ATP-dependent potassium channel [KCa or KATP] activator (other than bradykinin or a bradykinin analog), such as a direct potassium channel agonist or an indirect potassium channel activator, such as an activator of soluble guanylyl cyclase (e.g., nitric oxide or a nitric oxide donor) or an activator of cyclic GMP-dependent protein kinase, whereby the medicant is delivered selectively to the cells of the abnormal brain region and/or to the tumor, compared to normal tissues. Thus, among the disclosures is a method of treating a malignant tumor in a human subject. Also disclosed are pharmaceutical compositions that combine a potassium channel activator together with a medicant and a kit for enhancing the delivery of a medicant to an abnormal brain region and/or to a malignant tumor.
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申请公布号 |
WO0154680(A2) |
申请公布日期 |
2001.08.02 |
申请号 |
WO2001US02742 |
申请日期 |
2001.01.26 |
申请人 |
CEDARS-SINAI MEDICAL CENTER |
发明人 |
BLACK, KEITH, L.;NINGARAJ, NAGENDRA, S. |
分类号 |
A61K45/00;A61K31/00;A61K31/04;A61K31/198;A61K31/21;A61K31/282;A61K31/295;A61K31/401;A61K31/4025;A61K31/4245;A61K31/43;A61K31/44;A61K31/4409;A61K31/475;A61K31/495;A61K31/506;A61K31/513;A61K31/519;A61K31/655;A61K31/675;A61K31/69;A61K33/00;A61K33/04;A61K33/26;A61K38/00;A61K45/06;A61K45/08;A61K49/00;A61K49/04;A61K51/12;A61P25/00;A61P31/00;A61P35/00;A61P43/00;C12N15/88;(IPC1-7):A61K31/00 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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