PROCESS FOR SOLUBILIZING GLUCAGON-LIKE PEPTIDE 1 (GLP-1) COMPOUNDS

摘要

Disclosed is a method of preparing a GLP-1 compound that is soluble in aqueo us solution at pH 7.4 from a GLP-1 compound that is substantially insoluble in aqueous solution at pH 7.4. The insoluble GLP-1 compound is dissolved in aqueous base or in aqueous acid to form a GLP-1 solution. The GLP-1 solution is then neutralized to a pH at which substantially no amino acid racemizatio n of the GLP-1 compounds occurs, after which the soluble GLP-1 compound is isolated from the neutralized solution.